The effect of Chamomile Tea on Oral Mucositis among patients Undergoing Chemotherapy: Randomized Control Trail
Keywords:
Chamomile tea, Oral mucositis, ChemotherapyAbstract
Background: The side effect oral mucositis from chemotherapy harms patients who receive high-dose treatment because it affects 9 out of 10 individuals. The current oral medication palifermin needs extra funding to treat patients especially in less developed healthcare settings.Aim of study: This study aimed to test if chamomile tea can lower the harm oral mucositis causes from chemotherapy.Material and Method: Babylon oncology center in Iraq ran an official experiment with 75 patients split into two groups during medicinal studies. Card method was used to assign patients randomly into different groups. During two weeks’ participants in the chamomile group needed to apply chamomile tea rinses to their mouths three times a day but only standard medical care applied to the control group. WHO Mucositis Scale was used to measure oral mucositis severity in patients both at the start, day 7, and day 14.Results: The chamomile treatment sig nificantly reduced oral mucositis pain for patients but worsened symptoms for control patients (p < 0.001). Out of the 20 participants, 75% had no more mucositis by day 14. oral mucositis severity related closely to cancer stage, length of chemotherapy treatment and patient oral hygiene practices as tested with p values under 0.05. Standard oral care protocols for chemotherapy patients should include chamomile tea integration particularly in resource-limited healthcare facilities because it effectively decreases OM severity
References
Bzeipez, R. K., & Al-Fayyadh, S. (2022). Impact of cervical cancer on women’s bio-psycho-social aspects of health: A mixed methods study. Pakistan Journal of Medical & Health Sciences, 16(06), 668–673. https://doi.org/10.53350/pjmhs22166668
Al-Zaidy, S., & Al-Fayyadh, S. (2023). Efficacy of a pre-radiotherapy, nurse-led instructional program on anxiety level of patients receiving radiotherapy (RT) for first time. Onkologia i Radioterapia, 17(9), 370–378. https://www.oncologyradiotherapy.com/articles/efficacy-of-a-preradiotherapy-nurseled-instructional-program-on-anxiety-level-of-patients-receiving-radiotherapy-rt-for-first-time-103164.html
Miller, K. D., Nogueira, L., Devasia, T., et al. (2022). Cancer treatment and survivorship statistics, 2022. CA: A Cancer Journal for Clinicians, 72(5), 409–436.
Al‐Jubouri, M. B., Isam, S. R., Hussein, S. M., & Machuca‐Contreras, F. (2021). Recitation of Quran and music to reduce chemotherapy‐induced anxiety among adult patients with cancer: A clinical trial. Nursing Open, 8(4), 1606–1614. https://doi.org/10.1002/nop2.781
Sonis, S. T. (2023). The pathobiology of mucositis. Nature Reviews Cancer, 23(4), 216–230.
Villa, A., & Sonis, S. T. (2021). Mucositis: Pathobiology and management. Current Opinion in Oncology, 33(3), 159–164.
Elad, S., Cheng, K. K. F., Lalla, R. V., et al. (2020). MASCC/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy. Cancer, 126(19), 4423–4431.
Murphy, B. A., Beaumont, J. L., Isitt, J., et al. (2022). Mucositis-related morbidity and resource utilization in head and neck cancer patients receiving radiation therapy with or without chemotherapy. Journal of Pain and Symptom Management, 63(4), e387–e395.
Raber-Durlacher, J. E., Brennan, M. T., Verdonck-de Leeuw, I. M., et al. (2022). Interventions for preventing and treating oral mucositis in cancer patients: A systematic review. Oral Diseases, 28(4), 1025–1042.
Mohammed, A. J., & Mohammed, W. K. (2024). The relationship between patients’ chemotherapy-induced peripheral neuropathy and their demographic and clinical characteristics. Iraqi National Journal of Nursing Specialties, 37(1), 65–76. https://doi.org/10.58897/8e63ff90
Peterson, D. E., Boers-Doets, C. B., Bensadoun, R. J., et al. (2021). Management of oral and gastrointestinal mucositis: ESMO clinical practice guidelines. Annals of Oncology, 32(12), 1447–1456.
Rao, N. G., Rastogi, S., Mishra, N., et al. (2023). Challenges in standardizing oral mucositis assessment: A systematic review. Oral Oncology, 136, 106270.
Srivastava, J. K., Shankar, E., & Gupta, S. (2023). Chamomile: A herbal medicine of the past with bright future. Molecular Medicine Reports, 27(6), 112.
Abid, J. M., & Mohammed, W. K. (2021). Effectiveness of an instructional program on patients’ knowledge about home safety while receiving anti-cancer medications. Iraqi National Journal of Nursing Specialties, 34(2). https://doi.org/10.58897/injns.v34i2.571
Fadhil, I. A., & Hassan, H. B. (2018). Evaluation of nurses’ practices toward safe intravenous chemotherapy infusion. Iraqi National Journal of Nursing Specialties, 31(2). https://doi.org/10.58897/injns.v31i2.306
Mohammadi, F., Oshvandi, K., Kamallan, S. R., et al. (2022). Effectiveness of sodium bicarbonate and zinc chloride mouthwashes in the treatment of OM and quality of life in patients with cancer under chemotherapy. Nursing Open, 9(3), 1602–1611. https://doi.org/10.1002/nop2.1168
Al-Ganmi, A. H. A., Majeed, H. M., & Najm, M. A. (2024). Experiences of nurses in providing care for patients on the cancer journey: A cross-sectional survey. The Malaysian Journal of Nursing, 16(1), 212–219. https://doi.org/10.31674/mjn.2024.v16i01.021
Asad, M. J., & Majeed, H. M. (2024). Relationship between cigarette smoking and anxiety level among nurses. The Malaysian Journal of Nursing, 16(1), 149–158. https://doi.org/10.31674/mjn.2024.v16i01.015
Turke, A. F. A., & Majeed, H. M. (2024). Quality of life among epileptic patients after vagus nerve stimulator implantation: A cross-sectional study. Journal of Indian Academy of Forensic Medicine, 46(Suppl 1), 202–206. https://doi.org/10.48165/jiafm.2024.46.1(Suppl).24
Abed, O. A., & Majeed, H. M. (2024). Evaluation of patients’ knowledge concerning contributing factors and early detection of prostate cancer. Journal of Indian Academy of Forensic Medicine, 46(Suppl 1), 207–210. https://doi.org/10.48165/jiafm.2024.46.1(Suppl).25
Majeed, H. M., Hassan, A. F., & Al-Ganmi, A. H. A. (2024). Nurses’ performance and perceived barriers regarding pressure ulcers’ prevention for critically ill patients at Baghdad teaching hospitals. Journal of Nature and Science of Medicine, 7(4), 293–298. https://doi.org/10.4103/jnsm.jnsm_87_24
Ajil, Z. W., Majeed, H. M., & Al-Reda, J. J. (2024). Critical care nurses’ knowledge and perceived barriers regarding pressure injury prevention among critically ill patients at Baghdad teaching hospitals: A cross-sectional survey. International Journal of Critical Illness and Injury Science, 14(4), 215–220. https://doi.org/10.4103/ijciis.ijciis_60_24
Hassan, A. F., Majeed, H. M., & Isam, S. R. (2024). Nurses’ knowledge and protective health behaviors about prevention of COVID-19 pandemic complications at Baghdad teaching hospitals. Journal of Education and Health Promotion, 13(1), 107. https://doi.org/10.4103/jehp.jehp_844_23
Mohammed, T. R., Majeed, H. M., & Abid, R. I. (2020). Evaluation of quality of nursing documentation in surgical wards at Baghdad teaching hospitals. Medico-Legal Update, 20(3), 605–609. https://doi.org/10.37506/mlu.v20i2.1118
Hassan, A. F., Majeed, H. M., & Jasim, A. H. (2020). Assessment of undergraduate critical care nursing students’ knowledge and attitudes toward caring of dying patients in colleges of nursing at Baghdad University. Indian Journal of Forensic Medicine & Toxicology, 14(3), 1142–1146. https://doi.org/10.37506/ijfmt.v14i3.10530
Mohammed, T. R., Majeed, H. M., & Jasim, A. H. (2020). Evaluation of quality of nursing documentation in surgical wards at Baghdad teaching hospitals. Medico-Legal Update, 20(3), 292–297. https://doi.org/10.37506/mlu.v20i2.1118
Majeed, H. M., Hassan, A. F., & Kadhim, A. J. (2025). Students’ knowledge and attitude about hepatitis B and C viruses in Baghdad University. Medical Journal of Babylon, 22(1), 69–76. https://doi.org/10.4103/MJBL.MJBL_201_2
Hamadi, N. T., & Majeed, H. M. (2025). Exploring the effect of disruptive behavioral disorders on quality of learning among school children: A cross-sectional study. Journal of Forensic Medicine and Toxicology, 42(1), 164–169.
Elsehrawy, M. G., Ibrahim, N. M., Eltahry, S. I., & Elgazzar, S. E. (2024). Impact of educational guidelines on OM severity and quality of life in oncology patients receiving chemotherapy: A quasi-experimental study. Asian Pacific Journal of Cancer Prevention, 25(7), 2427–2438. https://doi.org/10.31557/APJCP.2024.25.7.2427
Göktuna, G., & Gürol Arslan, G. (2023). Investigation of OM incidence and risk factors in patients receiving chemotherapy. Journal of Basic and Clinical Health Sciences, 7(2), 747–755. https://doi.org/10.30621/jbachs.1199539
Abed, O. A., & Majeed, H. M. (2024). Patients’ attitudes concerning contributing factors and early detection of prostate cancer. International Journal of Academic Medicine, 10(3), 132–137. https://doi.org/10.4103/ijam.ijam_17_24
Asad, M. J., & Majeed, H. M. (2024). Association between personality traits and smoking cigarette among critical care nurses: A cross-sectional study. Journal of Forensic Medicine and Toxicology, 41(1), 168–174. https://acspublisher.com/journals/index.php/jfmt/article/view/17708
Turke, A. F. A., & Majeed, H. M. (2024). Assessment of psychosocial role for epileptic patients with vagus nerve stimulator implantation. Journal of Forensic Medicine and Toxicology, 41(1), 161–167. https://doi.org/10.48165/jfmt.2024.41.1.33
Abdulyemmah, A. D., & Majeed, H. M. (2025). Pain and satisfaction among type 2 diabetic patients: Effects of coughing, ShotBlocker and vibration during insulin injection: A randomized controlled trial. Nigerian Postgraduate Medical Journal, 32(2), 97–103. https://doi.org/10.4103/npmj.npmj_55_25
Vieira, J. S., Barros, A. M. I., Almeida, H. C. R. D., Sette de-Souza, P. H., Sobral, A. P. V., & Silveira, M. M. F. (2023). Efficacy of Matricaria recutita (chamomile) in the prevention and/or treatment of oral mucositis: Umbrella review. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 136(1), e36. https://doi.org/10.1016/j.oooo.2023.03.086
Santos, H. T. C., Coimbra, M. C., Meri Junior, A. E., & Gomes, A. J. P. S. (2021). Effectiveness of topically applied chamomile in the treatment of oral mucositis: A literature review. Research, Society and Development, 10(14). https://doi.org/10.33448/RSD-V10I14.22081
Supraja, T., R, S., M, R., Vv, B., Dhamodhar, D., S, S., et al. (2022). Effects of chamomile in the treatment of oral mucositis among patients undergoing chemotherapy and radiotherapy: A systematic review. https://doi.org/10.37591/rrjols.v12i3.3531
Ali, M., Kerio, A. A., Khattak, T. A., Khan, M. A., & Abbas, Y. (2023). Oral mucositis in patients undergoing hematopoietic stem cell transplantation. Journal of College of Physicians and Surgeons Pakistan, 33(7), 804–808. https://doi.org/10.29271/jcpsp.2023.07.804
Nishii, M., Soutome, S., Kawakita, A., et al. (2020). Factors associated with severe oral mucositis and candidiasis in patients undergoing radiotherapy for oral and oropharyngeal carcinomas: A retrospective multicenter study. Supportive Care in Cancer, 28(3), 1069–1075. https://doi.org/10.1007/s00520-019-04885-z
Allana, A., Shamsi, U., Rashid, Y., et al. (2024). Oral mucositis & oral health related quality of life in women undergoing chemotherapy for breast cancer in Karachi, Pakistan: A multicenter hospital based cross-sectional study. PLoS ONE, 19, e0295456. https://doi.org/10.1371/journal.pone.0295456
Iovoli, A. J., Turecki, L., Qiu, M. L., et al. (2023). Severe oral mucositis after intensity-modulated radiation therapy for head and neck cancer. JAMA Network Open, 6(10), e2337265. https://doi.org/10.1001/jamanetworkopen.2023.37265
McCullough, R. W. (2016). Actual duration of patient-reported mucositis: Far longer than 2 to 4 weeks and may be avoidable altogether. Korean Journal of Clinical Oncology, 12(1), 1–6. https://doi.org/10.14216/kjco.16001