Canine Parvovirus Infection: Clinical, Haemato-Biochemicaland Oxidative Stress Profiles
DOI:
https://doi.org/10.48165/ijvsbt.21.3.09Keywords:
Bloody diarrhoea, CPV, Frothy Vomiting, Lymphopenia, Neutrophilia, Oxidative stressAbstract
The study covered 57 dogs presented with haemorrhagic gastroenteritis at Veterinary Clinical Complex, Jabalpur from May to October 2024 which were confirmed positive for canine parvovirus via PCR. The most frequently observed clinical manifestations in this study were inappetence, frothy vomition, bloody diarrhoea, dehydration and depression. The haematological alterations revealed decreased levels of haemoglobin, total erythrocyte count, total leukocyte count, packed cell volume, neutrophilia and lymphopenia in CPV affected dogs as compared to healthy dogs. The serum levels of alkaline phosphatase and alanine aminotransferase were elevated, while the total protein and albumin levels were decreased. Oxidative stress parameters, viz., malondialdehyde was significantly higher, while reduced glutathione and catalase values were significantly lower in CPV affected dogs as compared to healthy controls.
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References
Berghoff, N., & Steiner, J.M. (2011). Laboratory tests for the diagnosis and management of chronic canine and feline enteropathies. Veterinary Clinics: Small Animal Practice, 41(2), 311-328.
Bhargavi, M., Shobhamani, K., Kumari, N., & Srilatha, C. (2017). Diagnostic aspects and haematobiochemical changes associated with canine parvoviral enteritis in dogs. International Journal of Current Microbiology and Applied Sciences, 6(11), 3357-
3364.
Bhat, A.A., Wadhwa, D.R., & Khan, M.A. (2013). Therapeutic management of canine parvoviral (CPV) gastroenteritis. Veterinary Practitioner, 14(1), 96-97.
Chauhan, D., Srivastava, A., Singh, A. P., Srivastava, M. K., & Verma, M. R. (2024). Assessment of efficacy of faecal antigen detection kit and occurrence of sepsis in canine parvovirus
enteritis in dogs. Indian Journal of Veterinary Sciences and Biotechnology, 20(4), 21-24.
Chethan, G.E. (2020). Therapeutic potential of antioxidants and egg yolk immunoglobulins as an adjunct therapy against canine parvovirus infection. M.V.Sc. Thesis. Indian Veterinary Research Institute, Izatnagar, UP, India.
Goth, L. (1991). A simple method for determination of serum catalase activity and revision of reference range. International Journal of Clinical Chemistry, 196(2-3), 143-151.
Harizan, I.M., Khinchi, R.K., Manju, S.S.K., & Meena, V.K. (2021). Alterations in haemato-biochemical and oxidative stress indices in dogs affected with parvoviral enteritis. The Journal of Pharm Innovation, 10(8), 428-431.
Kataria, D., Agnihotri, D., Jain, V., Charaya, G., & Singh, Y. (2020). Molecular occurrence and therapeutic management of canine parvovirus infection in dogs. International Journal of Current Microbiology and Applied Sciences, 9(2), 1770-1779.
Khanduri, R., Raval, S.K., Dave, K., & Rao, N. (2021). Haemato Biochemical Alterations in Dogs with Vomition. The Indian Journal of Veterinary Sciences and Biotechnology, 17(1), 52-55.
Khare, D.S., Gupta, D.K., Shukla, P.C., Das, G., Meena, N.S., & Khare, R. (2020). Clinical and haemato-biochemical changes in canine parvovirus infection. Journal of Pharmacognosy and Phytochemistry, 9(4), 1601-1604.
Kumar, A., & Kumar, R.K. (2017). Clinico-hematobiochemical changes in parvoviral infection in dog. International Journal of Science, Environment and Technology, 6(5), 2837-2841.
Kumar, R., Kumar, B., Kumar, S., Singh, M.K., & Kumar, R. (2020). Study of biochemical parameter in canine parvovirus infected canines. The Pharma Innovation Journal, 9, 40-43.
Mehta, S., Mavadiya, S., Parmar, S., Vagh, A., Vala, J., & Patel, R. (2020). Comparative economical analysis of the treatment adopted for canine parvo virus infected dog. Journal of Animal Research, 10(5), 843-848.
Mekky, R.H., Marawan, M.A., Moustafa, A.M., Selim, A., & and Shoulah, S. (2024). Oxidative stress markers and hematological parameters associated with canine parvoviral enteritis in dogs. Benha Veterinary Medical Journal, 47(1), 1-4.
Nath, M.K., Unny, N.M., Rajan, S.K., Pillai, U.N., & Ramnath, V. (2023). Evaluation of oxidative stress and efficacy of antioxidant
therapy in dogs with haemorrhagic gastroenteritis. Journal of Veterinary and Animal Sciences, 54(1), 86-90.
Panchsheel, Sarangmath P.S., & Chawan, P. (2024). Epidemiological and haemato-biochemical studies in parvoviral infected dogs. International Journal of Veterinary Sciences and Animal Husbandry, 9(1), 656-659.
Parthiban, S., Pothiappan, P., & Mukhopadhyay, H.K. (2016). Hematological and therapeutic aspects of canine parvovirus infection in non descript pups. Indian Veterinary Journal, 93(1), 35-37.
Patel, H.A., Rao, N., Bhanderi, B.B., Saiyad, S., Hadiya, K.K., & Patel, N. (2022). Diagnosis and incidence of canine parvovirus gastroenteritis. International Journal of Current Microbiology and Applied Sciences, 11(10), 222-229.
Prins H.K., & Loos J.A. (1969). Glutathione In: Yunis J.J. (ed.). Biochemical Methods in Red Cell Genetics, 1st Edn., Academic Press, New York, pp. 127-129.
Rathore, D., Khemada, D., Pandey, N., & Das, J. (2024). Study of haemato-biochemical alterations in gastroenteritis affected dogs. Veterinary Practitioner, 25(1), 11-14.
Rubio, C.P., Hernandez-Ruiz, J., Martinez-Subiela, S., Tvarijonaviciute, A., & Ceron, J.J. (2016). Spectrophotometric assays for total antioxidant capacity (TAC) in dog serum: an update. BioMed Central Veterinary Research, 12, 1-7.
Saravanan, S., Ramprabhu, R., Mohanapriya, T., Chitra, R., & Ponnu Swamy, K.K. (2020). Retrospective study on risk factors and haemato-biochemical alterations associated with canine parvoviral enteritis. Journal of Entomology and Zoology Studies, 8, 342-346.
Suleiman, S.A., Ali, M.E., Zaki, Z.M.S., El‐Malik, E.M.A., & Nasr, M.A. (1996). Lipid peroxidation and human sperm motility: Protective role of vitamin E. Journal of Andrology, 17(5), 530-537.
Valko, M., Leibfritz, D., Moncol, J., Cronin, M.T., Mazur, M., & Telser, J. (2007). Free radicals and antioxidants in normal physiological functions and human disease. The International Journal of Biochemistry and Cell Biology, 39(1), 44-84.
Zope, P.S., Waghmare, S.P., Pajai, K.S., Dighe, D.G., Hajare, S.W., & Kamdi, B.P. (2023). Molecular Diagnosis and haemato biochemical alterations in canine parvoviral infection in dogs. Indian Journal of Veterinary Sciences & Biotechnology, 19(5), 93.
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